Author/Authors :
Andisheh Tadbir، Azadeh نويسنده Department of Oral Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran , , Fattahi، Mohmmad Javad نويسنده Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences, Shiraz, Iran , , Khademi، Bijan نويسنده , , Pourshahidi، Sara نويسنده Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran , , Ebrahimi، Hooman نويسنده Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran , , Sardari، Yasaman نويسنده Department of Oral Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran , , Fattah، Zahra نويسنده School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran ,
Abstract :
Introduction: Galectin-3, a member of the family of B-galactoside-binding
animal lectins, has been implicated in tumor invasion and metastasis.
Materials and Methods: Using an ELISAkit, we assessed the circulating levels
of galectin-3 in sera from 40 oral squamous cell carcinoma (OSCC) patients and from
43 healthy controls.
Results: Serum galectin-3 levels in OSCC patients were significantly higher
(5.1±2.5 ng/ml) when compared with healthy controls (2.6±3.07 ng/ml, P < 0.0005).
There was no apparent correlation between serum galectin-3 concentration and
clinico-pathological features such as stage, tumor size, nodal status, distant metastasis
and histological grade.
Conclusion: This result suggests that, in addition to other tests, measurement of
serum galectin-3 concentrations can be utilized as an adjuvant test for establishing
a diagnosis of OSCC.
