Sildenafil Determination in Various Matrices: A Review

Determination of sildenafil by various methods and in various media is reviewed in this paper. The meth-ods used consist of ultraviolet (UV) spectroscopy, thin layer chromatography (TLC), and high-performance liquid chromatography (HPLC). These methods were used to determine the amount of sil-denafil in pharmaceutical preparations, soft drinks, and biological liquids. HPLC was used for evaluation of pharmacokinetic parameters of sildenafil. It is concluded that HPLC is the most reliable and applicable method in this regard.