Title of article :
Malonaldehyde formation and DNA fragmentation: two independent sperm decays linked to reactive oxygen specie
Author/Authors :
Debbie Montjean، نويسنده , , Yves Menezo، نويسنده , , Moncef Benkhalifa، نويسنده , , Marc Cohen، نويسنده , , Stephanie Belloc، نويسنده , , Paul Cohen-Bacrie and Jacques de Mouzon، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Abstract :
Malondialdehyde (MDA), a product involved in membrane lipid peroxidation, was dosed in the sperm of 163 patients who had consulted the clinic regarding hypofertility. We attempted to determine if there was correlation between MDA content, sperm World Health Organization parameters and DNA fragmentation that results mainly from reactive oxygen species assaults. We found that no correlation could be established; however MDA and sperm decondensation were shown to be significantly linked. The impact of membrane polyunsaturated fatty acids and the role of phospholipid hydroperoxide glutathione peroxidase are discussed.
Keywords :
DNA fragmentation , Lipid peroxidation , fatty acids , Malondialdehyde , reactive oxygen species
