Anticonvulsant and Antimicrobial Activity of Cu (II), Zn (II) and Co (II) Complex of Isatin 3-Glycine

The role of Cu, Zn and Co in human physiology is well documented. Isatin and glycine have inhibitory effects on central nervous system. To capitalize on these features metal complexes of isatin-3-glycine were prepared and evaluated for anticonvulsant activity. The Cu (II) complex was found to be most active among the compounds. The compounds were screened against Staphylococcus aureus, Escherichia coli and Pseudononas aeruginosa. Antimicrobial activity of ligand and its complexes were comparable to that of nitrofurantoin.