Olmsted Syndrome in an Iranian Family: Report of Two New Cases

Olmsted syndrome is a rare congenital entity characterized by combination of symmetrical, sharply-defined palmoplantar keratoderma with flexion deformities of the digits, periorificial keratosis, perianal involvement, onychodystrophy, and variable leukokeratosis. Herein, we report two new related male patients—the third familial cases of Olmsted syndrome—one with the full-blown spectrum of the syndrome, and the other with early signs and symptoms of the disorder.