Title of article
Synthesis and in vitro Cytotoxicity Studies of Novel Triazolo[4,3-b]pyridazinones
Author/Authors
E.M. Rakib، نويسنده , , S. Abouricha، نويسنده , , A. Hannioui، نويسنده , , N. Benchat، نويسنده , , L. Ait M’barek and A. Zyad، نويسنده ,
Issue Information
فصلنامه با شماره پیاپی سال 2006
Pages
5
From page
272
To page
276
Abstract
New triazolo[4,3-b]pyridazinones were synthesized and evaluated for their potential in vitro cytotoxic antitumor properties. The compounds were prepared by 1,3-dipolar cycloaddition of pyridazin-3-ones with N-aryl-C-ethoxycarbonylnitrile imines, generated in situ from ethylhydrazono-α-bromoglyoxylates. The peri- and regioselectivity of the reaction were ascertained by 1H and 13C NMR spectroscopy of the cycloadducts
Keywords
Cycloaddition , 3-b]pyridazinones , cytotoxicity , Hep cells
Journal title
Journal of the Iranian Chemical Society (JICS)
Serial Year
2006
Journal title
Journal of the Iranian Chemical Society (JICS)
Record number
666516
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