One-Pot Synthesis of 1-Aminophosphinic Acids Using 50% Hypophosphorus Acid under Microwave Irradiation

A simple and efficient method has been developed for the synthesis of α-aminophosphinic acids from hypophosphorus acid under solvent–free conditions using microwave irradiation. α-Aminophosphinic acids were obtained in high yield under mild conditions by reaction of hypophosphorus acid with aldehydes in the presence of amines under microwave irradiation