Convenient, Rapid and Eco-Friendly Synthesis of Isoxazoline Heterocyclic Moiety Containing Bridge at 2°-Amine as Potential Pharmacological Agent

2-Amino-4-(coumarin-3-yl)-thiazole (1) reacted with acetyl chloride gives compound (2) which on further refluxed with various aromatic aldehydes gives compound (3a-j). Thus obtained (3a-j) on further condensed with NH4OH.HCl using NaOH as a catalyst afforded isoxazoles (4a-j). All the synthesized compounds characterized on the basis of the IR, 1H NMR, 13C NMR and elemental analysis. All the compounds have been screened for antibacterial activity against bacteria (Gram + ve) & (Gram - ve) and antifungal activity