Uncatalyzed and Solvent-Free One-Pot Three Component Synthesis of α−Amino Phosphonates

An innovative route to preaper a number of variously substituted α-aminophosphonate is presented. The protocol avoids the use of any catalyst, organic solvents, and dry reaction conditions. The synthesis of α-aminophosphonates in the present study represents a three-component reaction in which no intermediate formation of either an imine or α-hydroxy phosphonate was observed