Synthesis, Physicochemical Investigation and Biological Studies of Zinc(II) Complexes with 1,2,4-Triazole Schiff Bases

A series of metal complexes of Zn(II) have been synthesized with newly synthesized biologically active 1,2,4-triazole Schiff bases derived from the condensation of 3-substituted-4-amino-5-mercapto-1,2,4-triazole with 8-formyl-7-hydroxy-4- methylcoumarin. The structure of the complexes has been proposed in the light of elemental analyses, spectroscopic data (IR, UV-Vis, 1H NMR and FAB-mass), thermal studies. Electrochemical study of the complexes is also reported. All the complexes are soluble to limited extent in common organic solvents but soluble to larger extent in DMF and DMSO and are non-electrolytes in these two solvent. All these Schiff bases and their complexes have also been screened for their antibacterial (Escherichia. coli, S. aureus, S. pyogenes, P. aeruginosa and Salmonella typhi) and antifungal activities (Aspergillus niger, Aspergillus flavus and cladosporium) by MIC method. The brine shrimp bioassay was also carried out to study their in vitro cytotoxic properties.