Green Protocol for Synthesis of the 3,5-Disubstituted 1,2,4-Thiadiazoles Using NBenzyl-DABCO-Tribromide in Aqueous Media

A novel and simple method for rapid conversion of thioamides to the corresponding 1,2,4-thiadiazole derivatives was developed. It was shown that, thioamides undergo clean and efficient oxidation and cyclization in their conversion to 1,2,4- thiadiazoles using N-benzyl-DABCO-tribromide in wet solid-solid conditions