Author/Authors :
Asvadi Kermani، Iraj نويسنده Haematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran , , Seifi، Sharaeh نويسنده Haematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran , , Dolatkhah، Roya نويسنده , , Asvadi Kermani، Atabak نويسنده Hematology and Oncology Research Center,Tabriz University of Medical Sciences , , Sakhinia، Ebrahim نويسنده Dept. of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , , Dastgiri، Saeed نويسنده , , Ebrahimi، Ayoub نويسنده Haematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran , , Lotfy، Alireza نويسنده Dept. of ENT, Tabriz University of Medical Sciences, Tabriz, Iran , , Esmaeili، Heidar نويسنده Dept. of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran , , Mohammadi، Ghodrat نويسنده Dept. of ENT, Tabriz University of Medical Sciences, Tabriz, Iran , , Naderpour، Masoud نويسنده Dept. of ENT, Tabriz University of Medical Sciences, Tabriz, Iran , , Hajalipour، Shabnam نويسنده Dept. of ENT, Tabriz University of Medical Sciences, Tabriz, Iran , , Asghari Haggi، Arezou نويسنده Haematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran , , Nadri، Mahsa نويسنده Haematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ,
Abstract :
Background: Epidemiologic and molecular evidences have established a strong link between high risk types of Human
Papilloma Virus and a subgroup of Head and Neck Squamous Cell Carcinomas
(HNSCC). We evaluated the frequency of HPV positivity in HNSCC and its
relationship to demographic and some risk factor variables in an open casecontrol
study.
Methods: Fourteen recently diagnosed patients with squamous cell cancer of
oropharynx, hypopharynx and larynx aged 18-50 years were examined from
2008-2010 in Tabriz, Iran. HPV DNA was extracted from paraffin-embedded
blocks of each patientʹs sample for PCR evaluation. Saliva samples of 94 control
cancer-free subjects were collected for DNA analysis. Multivariable logistic
regression method was used to calculate odds ratio for case-control comparisons.
Results: High risk HPV was detected in 6(42.8%) patients, and 6(5.3%) control
subjects which was statistically significant (p < 0.0001). HPV-18 was the most
frequent type both in the cases and controls. HPV-16 DNA was detected in two
patients of the case group, but it was not detected in any of the controls. The
relation between demographic and risk factor variables was not statistically
significant.
Conclusion: HPV infection has a significant impact on HNSCC. Despite HPV-16
stronger impact, HPV-18 is more likely to cause malignant degeneration in such
cancers amongst some communities. It is vital to introduce and conduct immunization
schedules in health care systems to protect communities to some extent
