Presence of Interferon-Gamma and IL-2 in Supernatants of Salmonella enteritidis-lmmune Lymphokines

Investigations in our laboratories have indicated that an increased resistance to Salmonella enteritidis SE organ infectivity in chickens was conferred by the immunoprophylactic administration of SE-immune lymphokines (SE-ILK). Resistance has been associated with an enhanced heterophilic accumulation within 4 h of ILK injection. Further studies demonstrated that CxCLi2 is produced locally by the host in response to both the SE infection and the SE-ILK suggesting that IL-8 is a major chemotactic factor produced by the host, which aids in mediating the SE-ILK induced recruitment of heterophils to the site of SE invasion. In the present study, two bio-assays confirmed the presence of IFN and IL-2 functions in SE-ILK that may also participate in the establishment of the reported protection against Salmonella infections. The IL-2 and IFN effects detected in this work suggest that birdʹs immune response develops similarly to that of mammals, with some features corresponding to the species.