Synthesis of Novel 2-Alkyl-5-{4-{(3-alkylisoxazol -5-yl)methoxy}phenyl}-2H-tetrazoles

Several alkyl(isoxazolylmethoxyphenyl)tetrazoles were synthesized and characterized. 3-Alkyl-5-(chloromethyl)isoxazoles 9 were prepared by the reaction of corresponding (3-alkylisoxazol-5-yl)methanols with thionyl chloride. 4-(2- Alkyl-2H-tetrazol-5-yl)phenols 8 were synthesized from the corresponding aldehyde 3 in five steps, which then reacted with 3-alkyl-5-(chloromethyl)isoxazoles 9 to produce the corresponding 2-alkyl-5-4-(3-alkylisoxazol-5-yl)methoxy phenyl-2H-tetrazoles 10a–h in high yields.