Author/Authors :
Vanda Vaz Serra، نويسنده , , Fatima Camoes، نويسنده , , Sandra I. Vieira، نويسنده , , Maria A. F. Faustino، نويسنده , , Joao P. C. Tome، نويسنده , , Diana C. G. A. Pinto، نويسنده , , Maria G. P. M. S. Neves، نويسنده , , Augusto C. Tome، نويسنده , , Artur M. S. Silva، نويسنده , , Edgar F. da Cruz e Silva، نويسنده , , Jose A. S. Cavaleiro، نويسنده ,
Abstract :
Studies on the synthesis, structural characterization and biological evaluation of novel chalcone-porphyrin derivatives are described. The photodynamic effect, intracellular localization and cellular uptake of the new conjugates were evaluated in vitro in COS-7 cells. All derivatives exhibited high stability and yielded good fluorescence under light irradiation. None of the chalcone-porphyrins proved to be cytotoxic and/or phototoxic for COS-7 cells.
Keywords :
Fluorine , medicinal applications , chalcones , Porphyrins , Fluorophores
