Silzic (ZnCl2/SiO2) as a New and Recyclable Zinc (II) Catalyst for One-pot Three-component Syntheses of β-aminocarbonyl Compounds under Solvent-free Conditions

Silzic (ZnCl2/SiO2) is an efficient and recyclable catalyst for one-pot three-component coupling reaction of aldehydes, amines and ketones to produce the corresponding β-aminocarbonyl compounds in high yields under solvent-free conditions. The advantages of this protocol are high yields, mild reaction conditions, simple work-up and less environmental pollution. In addition, the preparation of silzic is simple and has higher activity than homogeneous ZnCl2.