Synthesis, Spectral, Thermal Analysis, Biological Activity and Kinetic Studies of Copper(II)-Pyridine-2,5- dicarboxylate Complexes with 2-Aminomethylpyridine and 8-Hydroxyquinoline

In this work we report the synthesis of two novel square-planar copper(II) complexes, namely, (2-aminomethylpyridinium- pyridinedicarboxylato)copper(II) dihydrate, [Cu(pydc)(2-amp)]・ 2H2O (1) and (8-hydroxyquinolinum-pyridinedicarboxylato) copper(II) hydrate, [Cu(pydc)(8-HQ)]・ H2O (2) (2-amp = 2-aminomethylpyridine, 8-HQ = 8-hydroxyquinoline, H2pydc = pyridine-2,5-dicarboxylic acid or isocinchomeronic acid) and present the first preliminary study on kinetics and biological activities of copper complexes. The synthesized complexes have been characterized by elemental, spectroscopic (FT-IR, UV and mass spectra), thermal analysis, magnetic and conductivity measurements techniques. Kinetic parameters were obtained for each stage of thermal degradation of the complexes using Coats–Redfern and Horowitz–Metzger methods. Antimicrobial activities of two complexes and two ligands were evaluated using agar diffusion method. Antimicrobial activity of complex 2 was determined with the agar dilution methods. The results were compared with two well known antibiotics, namely, tetracycline and nystatin.