Abstract :
The Group IV phospholipase A2 family is consisted of six intracellular enzymes. They catalyze hydrolysis of the sn-2 ester bond of glycerophospholipids, releasing fatty acid metabolites and lysophospholipids. Agonist-induced release of arachidonic acid for the production of eicosanoids by PLA2IValpha enzyme is important in regulating normal and pathological processes in a variety of target tissues. Here, we compare PLA2IValpha, and its paralogs β, γ, δ, ε and ζ in term of of their structure, function and regulation.
Keywords :
Group IV phospholipase A2 , Cytosolic phospholipase A2 , arahidonic acid , C2 domain
