Title of article
The Evolution of αD-Conopeptides Targeting Neuronal Nicotinic Acetylcholine Receptors
Author/Authors
Dietrich Mebs، نويسنده , , Dusan Kordis، نويسنده , , Yvonne Kendel، نويسنده , , Silke Kauferstein، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2011
Pages
5
From page
730
To page
734
Abstract
Venoms of the marine cone snails (Conus spp.) consist of numerous proteins and peptides showing a wide variety of biological activities such as on ion-channels and receptors. Peptides acting on neuronal nicotinic acetylcholine receptors belong to several peptide superfamilies including the recently described αD-conopeptides which are homodimers of identical peptides with 47–49 amino acids. Among the venom glands of 27 Conus species analyzed by cDNA cloning, precursors of αD-conopeptides were identified in four species only: C. betulinus, C. capitaneus, C. mustelinus, and C. vexillum. Phylogenetic analysis of the relationships among the αD-conopeptides revealed that they belong to clades, which are characterized by an AVV- and EMM-motif in the signal peptide sequence.
Keywords
?D-conopeptide superfamily , Conus , conopeptides , Neuronal nicotinic acetylcholine receptor
Journal title
Acta Chimica Slovenica
Serial Year
2011
Journal title
Acta Chimica Slovenica
Record number
672423
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