Development of a Bolus Injection System to Achieve Storage and Controlled Delivery of Nanoparticles to Human Lung

This paper presents work carried out in developing a precision, bolus injection system to study the effect of regional deposition of fine particulate matter (PM) within the human respiratory system and to investigate the optimal conditions for inhaled drug delivery. In contrast to existing methods, the new system computes parameters necessary and injects PM into breath cycles by a process of dynamic breath pattern analysis and statistical data relating to stored PM to achieve a highly controlled delivery within specified exposure times and intervals.