Author/Authors :
Moradi، Mahmoudreza نويسنده , , Moradi، Asaad نويسنده Fertility-Infertility Research Center, Urology and Nephrology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermansh , , Alemi، Mohsen نويسنده Fertility-Infertility Research Center, Urology and Nephrology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermansh , , Ahmadnia، Hassan نويسنده , , Abdi Oskooei، S. Hossein نويسنده , , Ahmadi، Alireza نويسنده , , Bazargan-Hejazi، Shahrzad نويسنده Department of Psychology, College of Medicine, Charles Drew University of Medicine and Science, David Geffen School of Medicine, UCLA, Los Angeles, CA ,
Abstract :
Purpose: To compare the effects of L-carnitine with clomiphene citrate in idiopathic infertile men. Materials and Methods: Fifty-two men with idiopathic infertility were recruited in this randomized controlled trial. They were randomly assigned into 2 treatment groups, group 1 (n = 20) and group 2 (n = 32), who received L-carnitine 25 mg/day and clomiphene citrate 2 gr/day, respectively, for a period of 3 months. Results: Comparing the effect of L-carnitine and clomiphene on sperm parameters before and after the treatment, both medications had influence on sperm count and motility (P = .01). L-carnitine significantly increased the semen volume (P = .001), while clomiphene citrate was significantly associated with the motility percentage and normal morphology (P = .008). Conclusion: It seems that the use of clomiphene citrate and L-carnitine, either individually or in combination, as the first step of idiopathic male infertility treatment is reasonable, safe, and effective.
