A Comparison of Healing Effects of Propolis and Silver Sulfadiazine on Full Thickness Skin Wounds in Rats

Healing effects of propolis and silver sulfadiazine (SS) on skin wounds in rats were compared using qualitative and quantitative parameters and histopathological findings. A total of 30 full thickness skin wounds were created on dorsal aspects of 10 rats; i.e., three wounds on each rat. Of these wounds, 10 each were allocated to group A (propolis), group B (SS) and group C (control). The skin wounds in the rats of groups A, B and C were covered daily for 14 days with 50% propolis cream, SS skin cream and bepanthane cream (control), respectively. Postoperatively, the wound surfaces were examined macroscopically and the healing process and the rates of wound expansion, contraction and epithelialization processes were quantitatively analyzed. As a result, propolis was found in general to have a better wound healing effect than others. At the 10th day of experiment histopathologically, there was inflammatory reaction with infiltration of lymphocytes, macrophages and neutrophils and proliferation of fibroblastic loose connective tissue in dermis of rats of all groups. The severity of these changes was lower in propolis treated group compared to other two groups.