Author/Authors :
Elisa Visani، نويسنده , , LudovicoMinati، نويسنده , , Laura Canafoglia، نويسنده , , Isabella Gilioli، نويسنده , , Lucia Salvatoni، نويسنده , , Giulia Varotto، نويسنده , , Patrik Fazio، نويسنده , , Domenico Aquino، نويسنده , , Maria Grazia Bruzzone، نويسنده , , Silvana Franceschetti، نويسنده , , and Ferruccio Panzica، نويسنده ,
Abstract :
We performed simultaneous acquisition of EEG-fMRI in seven patients with Unverricht-Lundborg disease (ULD) and in six healthy controls using self-paced finger extension as a motor task. The event-related desynchronization/synchronization (ERD/ERS) analysis showed a greater and more diffuse alpha desynchronization in central regions and a strongly reduced post-movement beta-ERS in patients compared with controls, suggesting a significant dysfunction of the mechanisms regulating active movement and movement end. The event-related hemodynamic response obtained from fMRI showed delayed BOLD peak latency in the contralateral primary motor area suggesting a less efficient activity of the neuronal populations driving fine movements, which are specifically impaired in ULD.
