Author/Authors :
Li، Rong-Tao نويسنده , , Han، Quan-Bin نويسنده , , Zheng، Yong-Tang نويسنده , , Wang، Rui-Rui نويسنده , , Yang، Liu-Meng نويسنده , , Lu، Yang نويسنده , , Sang، Su-Qin نويسنده , , Zheng، Qi-Tai نويسنده , , Zhao، Qin-Shi نويسنده , , Sun، Han-Dong نويسنده ,
Abstract :
Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C (1–2), were isolated from Schisandra micrantha; micrandilactone C (2) exhibited an EC50 value of 7.71 (mu)g/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of 2 make it a promising lead for therapeutic development of a new generation of anti-HIV drug.
