Author/Authors :
Sarlati، Fatemeh نويسنده Department of Periodontics, Dental Branch, Islamic Azad University, P.O. Box 19585-175, Tehran, I.R. Iran , , Rahbarizadeh، Fatemeh نويسنده , , Aghaha، Shiva نويسنده Department of Periodontics, Dental Branch, Islamic Azad University, P.O. Box 19585-175, Tehran, I.R. Iran , , Ghorbani Gazar، Ali نويسنده Department of Periodontics, Dental Branch, Islamic Azad University, P.O. Box 19585-175, Tehran, I.R. Iran , , Mozaffari، Alireza نويسنده Department of Periodontics, Dental Branch, Islamic Azad University, P.O. Box 19585-175, Tehran, I.R. Iran ,
Abstract :
هدف عمده اين مطالعه بررسي وضعيت پلي مرفيسم ژن RANKL6-7 در بيماران مبتلابه پريودنتيت مزمن(خفيف،متوسط،پيشرفته) ، پريودنتيت مهاجم و همچنين افراد سالم مي باشد. 80 بيمار جهت بررسي پلي مرفيسم ژن هاي RANKL6-7 (rs1054016 and rs9567000) مورد معاينه قرار گرفتند.پلي مرفيسم توسط Polymerase chain reaction(PCR) و به دنبال آن sequencing مستقيم تعيين گرديد. ازنظر آماري اختلاف معني داري بين پلي مرفيسم ژن RANKL-7 و بيماري پريودنتال مشاهده نشد(P < 0.55) . همچنين هيچ آلل پلي مرفيك در ژن RANKL-6 جمعيت مورد مطالعه وجود نداشت.نتايج مطالعه حاضر نشان مي دهد كه بين پلي مرفيسم ژن هاي RANKL مورد بررسي و پريودنتيت مزمن/مهاجم ارتباطي وجود ندارد
Abstract :
The primary aim of this study was to investigate the status of RANKL6-7 gene polymorphism in patients with chronic (mild, moderate, severe) and aggressive periodontitis as well as healthy controls. We examined 80 patients for the RANKL6-7 polymorphisms (rs1054016 and rs9567000). Polymorphism was determined by polymerase chain reaction (PCR) followed by direct sequencing. No statistically significant association was found between the polymorphism in the RANKL 7 gene and periodontal disease (P < 0.55). There was also no polymorphic allele observed in RANKL 6 gene of the study population. We found no association between the studied RANKL polymorphisms and chronic/aggressive periodontitis.
