Title of article
The nature of the DNA template (single- versus double-stranded) affects the rate of aquation of a dinuclear Pt anticancer drug
Author/Authors
Farrell، Nicholas نويسنده , , Davies، Murray S. نويسنده , , Berners-Price، Susan J. نويسنده , , Cox، John W. نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
-121
From page
122
To page
0
Abstract
The rate of aquation of a dinuclear platinum anticancer agent is altered in the presence of template DNA with enhancement of hydrolysis in the presence of single-stranded over double-stranded DNA, emphasising how the alteration of chemical properties of small molecules in the presence of large host interactions is also dependent on the conformation and nature of that host.
Journal title
CHEMICAL COMMUNICATIONS - LETCHWORTH
Serial Year
2003
Journal title
CHEMICAL COMMUNICATIONS - LETCHWORTH
Record number
68175
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