Author/Authors :
Mohammadpour، Hossein نويسنده Department of Microbiology, Masjed Soleiman Branch, Islamic Azad University, Masjed Soleiman, IR Iran Mohammadpour, Hossein , Moghimipour، Eskandar نويسنده , , Rasooli، Iraj نويسنده , , Fakoor، Mohammad Hadi نويسنده Department of Microbiology, Hidaj Branch, Islamic Azad University, Hidaj, IR Iran Fakoor, Mohammad Hadi , Astaneh، Shakiba نويسنده Department of Biology, Shahed University, Tehran, IR Iran Astaneh, Shakiba , Shehni Moosaie، Sara نويسنده Department of Microbiology, Masjed Soleiman Branch, Islamic Azad University, Masjed Soleiman, IR Iran Shehni Moosaie, Sara , Jalili، Zeynab نويسنده Department of Microbiology, Masjed Soleiman Branch, Islamic Azad University, Masjed Soleiman, IR Iran Jalili, Zeynab
Abstract :
Aflatoxin B1 (AFB1) is a highly toxic and hepatocarcinogenic metabolite produced
by Aspergillus species. Some natural products are known to kill fungi and destroy
toxins and toxin-producing agents.
Objectives: The purpose of this study is to provide experimental data on the antifungal
activity of cumin oils and their components that could be considered suitable for application
in foods and drugs.
Materials and Methods: The essential oil (EO) of Cuminum cyminum L. collected from
Alborz Mountain, Iran, was obtained by hydro-distillation. The oil was analyzed by gas
chromatography (GC) and chromatography/mass spectrophotometry (GC/MS). The antifungal
activity of the oil was studied with regard to the inhibition of the growth of Aspergillus
flavus PICC-AF39 , Aspergillus flavus PICC-AF24, Aspergillus parasiticus NRRL-2999 and
Aspergillus niger. The minimal inhibitory (MIC) and minimal fungicidal (MFC) concentrations
of the oil were determined.
Results: ?–Pinene (29.2%), limonene (21.7%), 1,8-cineole (18.1%), linalool (10.5%), linalyl acetate
(4.8%), and ?-terpineole (3.17%) were the major components of the essential oil from
C. cyminum L., and the oil showed a strong inhibitory effect on fungal growth.
Conclusions: Essential oils could be safely used as preservatives in pharmaceuticals as
well as health and food products to protect them against toxigenic fungal infections.
