Title of article :
Association of G/A Polymorphism, rs266882, in AREI Region of the Prostate-Specific Antigen Gene with Prostate Cancer Risk and Clinicopathological Features
Author/Authors :
Samzadeh، Mohammad نويسنده , , Hasanzad، Mandana نويسنده Tehran Medical Branch, Islamic Azad University, Tehran , , Jamaldini، Seyed Hamid نويسنده Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran , , Haghdoost، Ali Akbar نويسنده Research Center for Modeling of Health, Kerman University of Medical Sciences, Kerman , , Afshari، Mahdi نويسنده Research Center for Modeling of Health, Kerman University of Medical Sciences, Kerman , , Ziaee، Seyed Amir Mohsen نويسنده Urology and Nephrology Research Center, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran ,
Abstract :
Purpose: To determine the association of prostate-specific antigen (PSA) 158A/G polymorphism with clinicopathologic characteristics of the disease and prostate cancer (PCa) risk.
Materials and Methods: Two hundred and six subjects, including 95 patients with PCa and 111 subjects with benign prostatic hyperplasia (BPH), were recruited in this study. Genotyping was performed by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism method.
Results: Presence of GG genotype significantly increased the risk of PCa more than 2-fold compared to AG genotype (adjusted odds ratio = 2.4; P = .03). The percentages of G alleles of polymorphisms in patients with PCa were more than that in ones with BPH (odds ratio = 1.2; P = .7).
Conclusion: The GG genotype of PSA 158A/G polymorphism is a predisposing factor for PCa. But no association was observed between alleles and grade, stage, or age of diagnosis. Similarly, the rs266882 polymorphism was not associated with PSA plasma levels.
