Author/Authors :
Pakkir Maideen، Naina Mohamed نويسنده School of Pharmacy, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Chennai-600 117, India. , , Velayutham، Ravichandiran نويسنده School of Pharmacy, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Vels University, Chennai-600 117, India. , , Manavalan، Gobinath نويسنده Ratnam Institute of Pharmacy, Pidathapolur (V & Post), Muthukur (M), Nellore-524 346, Andhra Pradesh, India. ,
Abstract :
Purpose: The objective of the present study was to evaluate the protective effect of methanol extract of Prosopis cineraria (MPC) against N-nitrosodiethylamine (DEN, 200mg/kg) induced Phenobarbital promoted experimental liver tumors in male Wistar rats. Methods: The rats were divided into four groups, each group consisting of six animals. Group 1 served as control animals. Liver tumor was induced in group 2, 3, and 4 and Group 3 animals received MPC 200mg/kg and Group 4 animals received MPC 400mg/kg. Results: Administration of DEN has brought down the levels of membrane bound enzymes like Na+/ K+ ATPase, Mg2+ ATPase and Ca2+ATPase which were later found to be increased by the administration of Prosopis cineraria (200 and 400mg/kg) in dose dependent manner. The MPC extract also suppressed the levels of glycoproteins like Hexose, Hexosamine and Sialic acid when compared to liver tumor bearing animals. Conclusions: Our study suggests that MPC may extend its protective role by modulating the levels of membrane bound enzymes and suppressing glycoprotein levels.
