Asymmetric synthesis of (alpha)-aminoamides by Pd-catalyzed double carbohydroamination

Tris(dibenzylideneacetone)dipalladium(0)[Pd2(dba)3] catalyzed asymmetric double carbohydroamination of iodoarenes in the presence of a chiral ligand (Trost ligand and Me-DuPHOS are most effective) is an excellent method for the chiral synthesis of (alpha)-aminoamides in up to 99% ee.