Title of article
Rapid screening by MALDI-TOF mass spectrometry to probe binding specificity at enzyme active sites
Author/Authors
Abell، Chris نويسنده , , Webb، Michael E. نويسنده , , Stephens، Elaine نويسنده , , Smith، Alison G. نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2003
Pages
-2415
From page
2416
To page
0
Abstract
The binding affinity of aspartate decarboxylase has been probed using MALDI-TOF spectrometry; adducts formed covalently in the active site were detected by MALDI-TOF mass spectrometry after incubation of the enzyme with a range of potential ligands in the presence of NaCNBH3; this has highighted key structural features which will aid design of potential inhibitors.
Keywords
starburstinfrared , evolution galaxies
Journal title
CHEMICAL COMMUNICATIONS - LETCHWORTH
Serial Year
2003
Journal title
CHEMICAL COMMUNICATIONS - LETCHWORTH
Record number
68493
Link To Document