Glyco-helix: parallel lactose-lactose interactions stabilize an alpha-helical structure of multi-glycosylated peptide

Glyco-helix is designed as a novel model system to investigate cis carbohydrate–carbohydrate interactions. Adhesive Lac–Lac interactions stabilize alpha-helix of Lac-peptide in the presence of fluorinated alcohols, but no such an interaction was observed in GlcNAc-peptide.