Author/Authors :
Rezk، Mamdouh R. نويسنده Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt , , Michael، Adel M. نويسنده Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University,Egypt , , Lotfy، Hayam M. نويسنده 1Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt , , Shehata، Mostafa A. نويسنده ,
Abstract :
A novel sumatriptan (SUM) selective electrode was investigated with dioctyl
phthalate as a plasticizer in a polymeric matrix of carboxylated polyvinyl chloride (PVCCOOH),
based on the interaction between the drug solution and the dissociated COOH
groups in the PVC-COOH. The sensor was fabricated by using PVC-COOH only as anionic
site without incorporation of an ionophore. Linear response of SUM within a concentration
range of 10-6-10-3 M with a slope of 34±1 mV/decade over pH range of 6-8 was observed.
The measurement was characterized by a fast stable response within about 45 seconds.The
proposed sensor was successfully applied for the selective determination of sumatriptanin the
pure powder form and in its pharmaceutical formulation with naproxen without any
interference. The results obtained by the proposed procedure were statistically analyzed and
compared with those obtained by the U.S. Pharmacopeia method. No significant difference
for either accuracy or precision was observed.
