Effect of Ethanolic Extract of Bauhinia Monandra Leaf on the Liver of Alloxan Induced Diabetic Rats

The leaf extract of Bauhinia monandra was investigated in the liver of alloxan induced diabetic rats for 8 days. Thirty male albino rats were randomly divided into 6 groups of 5 each. The groups administered with 1g/kg and 2g/kg of B. monandra extract were statistically different from the normal control animals. The treatment of diabetes with 4g/kg on rats showed significant difference on the 1st and 2nd days but there were no significant differences from the 3rd to the 8th day. Aspartate transaminase and alanine transaminase levels dropped in rats administered with 2g/kg and 4g/kg, but there was no significant difference with 1g/kg. Our results demonstrate that extracts of B. monandra showed significant reduction of blood sugar level in diabetic rats as well as hepatoprotective effect on the liver when the extracts were administered in a single dose per day of 1, 2 and 4mg/ kg body weight ip respectively. The extract can therefore be used for the reduction of blood sugar level.