Author/Authors :
فاضلي، يوسف نويسنده Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute, Atomic Energy Organization of Iran, Karaj, I Fazaeli, Yousef , جليليان ، اميررضا نويسنده Jalilian, A.R , كمالي دهقان، محسن نويسنده سازمان انرژي اتمي ايران,پژوهشگاه علوم و فنون هسته اي , , بلوري نوين، فاطمه نويسنده سازمان انرژي اتمي ايران,پژوهشگاه علوم و فنون هسته اي , , مرادخاني، صديقه نويسنده سازمان انرژي اتمي ايران Moradkhani, S , اصلاني كردكندي، غلامرضا نويسنده , , محمدرضا رحيمي نژاد، علي اصغر معصومي نويسنده , , قنادي مراغه، محمد نويسنده Ghannadi Maragheh, M
Abstract :
Introduction: [64Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([64Cu]ATSM) is a well-established hypoxia
imaging tracer with reproducible production and significant specifity. In this work the high yield production and
quality control as well as imaging studies in healthy rabbits is reported.
Methods: Copper-64 produced via the 68Zn(p,?n)64Cu nuclear reaction (30 MeV protons at 180 ?A) was used for
the preparation of [64Cu]diacetyl-bis(N4-methylthiosemicarbazone)([64Cu]ATSM). Followed by quality control and
administration to healthy rats as well as healthy rabbits for biodistribution and imaging studies respectively.
Results: 64Cu2+ (500 mCi, separation yield > 95%, radionuclide purity > 96%) was used for [64Cu]ATSM production
(radiochemical purity > 99%, specific activity of 300 Ci/mmol) followed by administration to healthy rabbits and
coincidence imaging demonstrating uptake in liver, kidney and bowel as shown by other reports in various rodents
and human.
Conclusion: [64Cu]ATSM radiopharmaceutical is produced and now available in large quantities for research and/or
clinical trials in the country.
