Author/Authors :
A.A.G، Atsang نويسنده Department of Agriculture, Livestock and By-products, the Higher Institute of the Sahel, Po. Box: 46, University of Maroua, Cameroon , , D.P. D، Dzeufiet نويسنده Laboratory of Animal Physiology, Faculty of sciences, Po. Box: 812, University of Yaoundé I, Cameroon , , H. S، Foyet نويسنده Department of Agriculture, Livestock and By-products, the Higher Institute of the Sahel, Po. Box: 46, University of Maroua, Cameroon , , P، Nana نويسنده School of Wood, Water and Natural Resources, Faculty of Agriculture and Agricultural Sciences, University of Dschang, Cameroon , , D. S، Sokeng نويسنده Department of Biological Sciences, Faculty of sciences, Po. Box: 565, University of Ngaoundéré, Cameroon , , T، Dimo نويسنده Laboratory of Animal Physiology, Faculty of sciences, Po. Box: 812, University of Yaoundé I, Cameroon , , P، Kamtchouing نويسنده Laboratory of Animal Physiology, Faculty of sciences, Po. Box: 812, University of Yaoundé I, Cameroon ,
Abstract :
The present study has been undertaken to assess the analgesic and the anti-inflammatory properties of methanolic extract Dichrostachys glomerata fruit. Pain was induced in mice by the intraperitoneal administration of 1 % acetic acid, and formalin. Carrageenan and histamin (1%) were used to induce inflammation in rat paws. At the doses of 25 and 50 mg/kg, D. glomerata significantly inhibited pain induced by acetic acid with a percentage inhibition of 80.0 and 76.0 %, respectively. The neurogenic pain induced by formalin was significantly inhibited by the plant extract at the doses of 25 and 50 mg/kg (56.14 and 61.46% inhibition respectively) while the inflammatory phase was significantly inhibited at all the doses tested. The extract (25 mg/kg) significantly reduced oedema induced by carrageenan with 79.85 % inhibition at after 30 minutes while the oedema induced by the serotonin was also significantly inhibited the plant extract.
