Effect of Lepidium Sativum on Lipid Profiles and Blood Glucose in Rats

The present study was designed to investigate the effects of Lepidium sativum on the blood glucose and lipid profile in hypercholesterolemic rats. Fourty adult albino male rats were classified into three groups. One was fed on standard diet and kept as control group. The rest of rats were fed on standard diet with 4 % cholesterol for 2 weeks to be hypercholesterolemic, and then classified into 2 groups. Group I, hypercholesterolemic rats. Group II, alloxan treated animals. Both groups treated for 4 weeks with orally administered with Lepidium sativum extract (20 mg/kg). In comparison to control group, showed a significant lower value of plasma glucose 30%, cholesterol 22%, triglycerides 25%, LDL 23% and increase in HDL 32%. In conclusions, the findings of this study indicate that the administration of Lepidium sativum showed better lipid profile as well as decreases in the sugar level in hypercholesterolemic rats.