Author/Authors :
T. V، Dougnon نويسنده Interfaculty Center of Formation and Research in Environment for the Sustainable Development, Laboratory of Toxicology and Environmental Health , , J. R، Klotoé نويسنده Polytechnic School of Abomey-Calavi, Department of Human Biology, University of Abomey-Calavi, 01 BP 2009 Cotonou, Benin. , , P. A، Edorh نويسنده Interfaculty Center of Formation and Research in Environment for the Sustainable Development, Laboratory of Toxicology and Environmental Health , , J، Sègbo J نويسنده Polytechnic School of Abomey-Calavi, Department of Human Biology, University of Abomey-Calavi, 01 BP 2009 Cotonou, Benin. , , J. M، Atègbo نويسنده Faculty of Science and Technology, Department of Animal Physiology, University of Abomey-Calavi (UAC), 01 BP 526 Cotonou, Benin , , O. A، Sodipo نويسنده Department of Clinical Pharmacology and Therapeutics, College of Medical Sciences, University of Maiduguri, P.M.B. 1069 Maiduguri. , , T. J، Dougnon نويسنده Polytechnic School of Abomey-Calavi, Research Laboratory in Applied Biology, University of Abomey-Calavi, 01 BP 2009 Cotonou, Benin , , C، Dandjesso نويسنده Polytechnic School of Abomey-Calavi, Department of Human Biology, University of Abomey-Calavi, 01 BP 2009 Cotonou, Benin , , F، Loko نويسنده Polytechnic School of Abomey-Calavi, Department of Human Biology, University of Abomey-Calavi, 01 BP 2009 Cotonou, Benin , , K، Dramane نويسنده Faculty of Science and Technology, Department of Biochemistry and Cellular Biology, University of Abomey-Calavi (UAC), 01 BP 526 Cotonou, Benin ,
Abstract :
This study has evaluated the hemostatic potential of Jatropha multifida’s sap as traditional medicine in Benin attributed hemostatic properties to this substance. Several hemostatic tests as Blood Coagulation Time, Quick Time, Activated Cephalin Time, Test of Milk Precipitation, Total Protein of blood samples were performed at 37°C. Prothrombin Time (PT) revealed prior to thromboplastin’s addition, there was precipitation of the plasma in all tubes except the control tube (T0). After addition of thromboplastin, control tube coagulated in 78 seconds while all other tubes were not coagulated ( > 15 minutes). The same observations were made for the Activated Cephalin Time (ACT) for which prior to addition of cephalin activator, there was precipitation of plasma in all tubes except the control tube (T0). After addition of cephalin activator, the control tube was coagulated with 43.33 seconds while test tubes were not coagulated ( > 15 minutes). Blood coagulation time decreased regardless of the administered dose of sap. Time of milk’s precipitation showed the sap rushes milk proteins. This was confirmed by the determination of total proteins in serum; proteins which decreased by over 60% with ¼ dilution for example (p < 0.05). It has been proven that using sap of Jatropha multifida has some effects on hemostasis so its usage in traditional medicine is justified.
