Author/Authors :
Amare، Meareg نويسنده Department of Chemistry, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia , , Lakew، Worku نويسنده Department of Chemistry, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia , , Admassie، Shimelis نويسنده Department of Chemistry, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia ,
Abstract :
A polymer modified glassy carbon electrode was fabricated by
electropolymerizing 4-amino-3-hydroxynaphthalene sulfonic acid (AHNSA) in a 0.1 M
HNO3 and was characterized by cyclic voltammetry. The polymer modified electrode
showed an excellent electrocatalytic activity towards the electrochemical oxidation of
ephedrine. The oxidative peak current response of ephedrine at the polymer modified-glassy
carbon electrode was found to show linear dependence on the concentration of ephedrine in
the range of 8.0×10-6 to 1.0×10-3 mol L-1 with a linear regression equation, correlation
coefficient and limit of detection (according to S/N=3; for n=4) of Ipa(?A)=0.971+0.042 C
(?M), 0.99913 and 7.9×10-7 M, respectively. The proposed method was tested for the
determination of ephedrine in human urine. Recoveries ranging between 92.06–93.15% for
filtered and 81.15–86.30% for unfiltered human urine were achieved validating the
developed method.
