Author/Authors :
Vahedi Langrudi، Mohammad Mehdi نويسنده , , Malekzadeh، Hossein نويسنده Department of Oral Medicine, Dental Research Center, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran , , Haybar، Habib نويسنده Cardiovascular Research Center, Golestan Hospital, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran , , Soltanian، Ali Reza نويسنده Department of Biostatistics and Epidemiology, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran , , Abdollahzadeh، Shermin نويسنده Department of Oral Medicine, Dental Research Center, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran , , Yoosefi، Hojjat نويسنده Department of Periodontics, School of Dentistry, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran , , Seyedian، Masoud نويسنده Cardiovascular Research Center, Golestan Hospital, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran , , Yazdanpanah، Leila نويسنده . Cardiovascular Research Center, Golestan Hospital, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran , , Abrotan، Saeid نويسنده Cardiovascular Research Center, Golestan Hospital, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran , , Shabanpour Fooladi، Maryam نويسنده Department of Internal Medicine, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran , , Ghasemi، Marziyeh نويسنده Cardiovascular Research Center, Golestan Hospital, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran ,
Abstract :
Objective: This study defines the relationship between salivary beta-2 microglobulin (B2-M) and intensity of uremia in male patients diagnosed with chronic renal failure (CRF).
Materials and Methods: In total of 42 males were enrolled in a case-control study. There were 21 cases of CRF and 21 control cases. We collected 10cc of saliva plus 5 cc of blood from all patients to determine B2-M, blood urea nitrogen (BUN) and creatinine
(Cr) levels.
Results: There was a correlation between the level of serum BUN and salivary urea in controls and patients, which was statistically significant for controls (p=0.028).The correlation
between serum and salivary Cr was 0.195 in controls (p=0.398) and 0.598 in patients (p=0.006), which was statistically significant in patients. The correlation between serum and saliva was 0.133 (p=0.566) in controls and 0.078 (p=0.737) in patients, which was not statistically significant. The correlation between serum BUN and B2-M was 0.168 (p=0.469) in the control group and 0.629 (p=0.002) in patients, which was statistically significant in patients. The correlation between serum Cr and B2-M was 0.110 (p=0.635) in the control group and 0.678 (p=0.001) in patients, which was statistically significant in patients. The correlation between serum BUN and salivary B2-M was 0.093 (p=0.0690) in controls and 0.152 (p=0.152) in patients, which was not statistically significant. The correlation
between
serum
Cr
and
salivary
B2-M
was
0.072
(p=0.070)
in
the
control
group
and
0.286
(p=0.209) in patients, which was not statistically significant in either group.
Conclusion: The results of the study indicated that salivary B2-M cannot be used as a noninvasive
indicator to detect the severity of renal failure.
