• Title of article

    Targeting of mixed sequence double-stranded DNA using pyrene-functionalized 2-amino(alpha)-L-LNA

  • Author/Authors

    Hrdlicka، Patrick J. نويسنده , , Wengel، Jesper نويسنده , , Kumar، T. Santhosh نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2005
  • Pages
    -4278
  • From page
    4279
  • To page
    0
  • Abstract
    Incorporation of a single pyrene-functionalized 2-amino(alpha)-L-LNA monomer X into short DNA strands induces extraordinarily high binding affinity towards complementary DNA (up to 16 °C increase per modification), whereas labile duplexes, suitable as probes for targeting of double stranded DNA, are formed upon positioning of two monomers X in an interstrand +1 zipper motif.
  • Keywords
    Oxidation , H2O2 , Carbon-Fe catalysts , Fenton-like , Orange II
  • Journal title
    CHEMICAL COMMUNICATIONS - LETCHWORTH
  • Serial Year
    2005
  • Journal title
    CHEMICAL COMMUNICATIONS - LETCHWORTH
  • Record number

    70795

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=70795