Author/Authors :
Haghjooy Javanmard، Shaghayegh نويسنده Physiology Research Center , , Rabbani، Hossein نويسنده Medical Image and Signal processing research center ,
Abstract :
Genome-wide sequencing has empowered us to relate more and more events in healthy as well as disease-affected cells and tissues to the genomic sequence. Bioinformatics is a highly interdisciplinary field that aims to analyze genomic sequences and biological data. For this reason, methods and technologies from various disciplines from biology and medicine to mathematics, statistics, computer sciences, and physics are employed. In fact extracting knowledge from biological data is a very complex task because usually all the knowledge and skills needed to understand biological mechanisms are not available in a research group. As an example, after several decades of biological researches and a quarter century from establishment of biomedical engineering as an interdisciplinary field in Iran, only a few research groups are being founded that possess different expertise to solve bioinformatics problems. Although single disciplinary research teams have been worked in the field of bioinformatics from years ago, nowadays high -throughput experimental methods in molecular biology r esult in an enormous amount of data, including interactions, networks, and pathways [2][1] that could not been evaluated only by a single discipline. Therefore, it is essential to have a research team with intensive interaction among a multitude of actors such as mathematicians and computer scientists in order to provide new tools to reveal the essential biological mechanisms from a system perspective for the next-generation sequencing (NGS). [3]