Author/Authors :
Hojabri، Zoya نويسنده Tabriz Research Center of Infectious and Tropical Diseases, Tabriz University of Medical Sciences, Tabriz, Iran. , , Ahangarzadeh Rezaee، Mohammad نويسنده Tabriz Research Center of Infectious and Tropical Diseases, Tabriz University of Medical Sciences, Tabriz, Iran. , , Nahaei، Mohammad Reza نويسنده , , Soroush، Mohammad Hossein نويسنده Tabriz Research Center of Infectious and Tropical Diseases, Tabriz University of Medical Sciences, Tabriz, Iran. , , Ghojazadeh، Morteza نويسنده PhD, Assistant Professor, Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Ghojazadeh, Morteza , Pirzadeh، Tahereh نويسنده Tabriz Research Center of Infectious and Tropical Diseases, Tabriz University of Medical Sciences, Tabriz, Iran. , , Davodi، Mostafa نويسنده Tabriz Research Center of Infectious and Tropical Diseases, Tabriz University of Medical Sciences, Tabriz, Iran. , , Ghazi، Mona نويسنده Tabriz Research Center of Infectious and Tropical Diseases, Tabriz University of Medical Sciences, Tabriz, Iran. , , Bigverdi، Reza نويسنده Tabriz Research Center of Infectious and Tropical Diseases, Tabriz University of Medical Sciences, Tabriz, Iran. , , Pajand، Omid نويسنده , , Aghazadeh، Mohammad نويسنده Tabriz Research Center of Infectious and Tropical Diseases, Tabriz University of Medical Sciences, Tabriz, Iran. ,
Abstract :
Purpose: The antimicrobial activity of doripenem in comparison of imipenem, meropenem and ertapenem among Pseudomonas aeruginosa isolated from burn and Cystic Fibrosis (CF) patients were determined. Methods: Metallo-B-lactamase (MBL) genes in imipenem non susceptible P. aeruginosa isolates were detected using PCR method. The in vitro susceptibilities of doripenem, imipenem, meropenem and ertapenem were determined by Etests. MIC50 and MIC90 for corresponding antibiotics were determined individually in burn and CF isolates. Results: Among isolates which were resistant to imipenem, 16 isolates were positive for the bla IMP gene. All isolates had no bla VIM gene. All MBL producing isolates were excluded. MIC50/MIC90 of doripenem in CF and burn isolates were 0.75/ > 32 and > 32/ > 32 mg/L respectively. The corresponding values for imipenem in CF and burn isolates were 2/ > 32 and > 32/ > 32 mg/L, respectively. Conclusion: The susceptibility rate of doripenem is higher than that of imipenem and meropenem among P.aeruginosa isolated from CF patients, whereas, there is no difference between the efficiency of doripenem and old carbapenems in non MBL producing P.aeruginosa isolates in burn patients.
