Expected Mean Squares for Hierarchical Factorial Layouts with Population Imbalance

We introduce an analysis of variance usable for two-factor hierarchical models where observations are incompletely sampled from unbalanced populations of finite effects. Our new approach enables unbiased estimation of the variance components for this type of model and allows hypothesis testing to identify significant effects/sub-class effects. An explanation of how these results can be generalized to factorial layouts with more than two factors is given