Author/Authors :
Shahabi، Sima نويسنده Physiology and Pharmacology Department, Babol University of Medical Science, Babol, Iran , , Jorsaraei، Seyed Gholam Ali نويسنده Fatemeh Zahra Infertility and Health Reproductive Research Center, Babol University of Medical sciences, Babol, Iran , , Moghadamnia، Ali Akbar Ali Akbar نويسنده Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran Moghadamnia, Ali Akbar Ali Akbar , Zabihi ، Ebrahim نويسنده Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran Zabihi , Ebrahim , Aghajanpour Mir ، Seyed Mohsen نويسنده Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran , , Mousavi Kani، Seyedeh Narges Seyedeh Narges نويسنده Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. Mousavi Kani, Seyedeh Narges Seyedeh Narges , Pourbagher، Roghieh Roghieh نويسنده Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. Pourbagher, Roghieh Roghieh , Hosseini ، Seyed Ahmad نويسنده , , Esmaili، Mohsen Mohsen نويسنده Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Esmaili, Mohsen Mohsen , Yoonesi، Ali Asghar Ali Asghar نويسنده Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Yoonesi, Ali Asghar Ali Asghar , Zarghami، Amin Amin نويسنده Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Zarghami, Amin Amin , Alinezhad، Farid Farid نويسنده Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Alinezhad, Farid Farid
Abstract :
In Persian traditional medicine is believed that camphor (a crystalline ketone obtained from cinnamomum camphora) is a suppressor of sexual behaviors. This study examined the central effects of camphor on sexual hormones (LH, FSH and testosterone) and GnRH plasma levels in male rat.
Male Wistar rats weighing 250-260gr were selected and divided into control (no treatment), sham (ICV injection of EtOH 10%) and treatment (ICV injection of camphor in three doses 4, 20, 40 µg/ 10µl in alcohol) groups. The serum samples were used for assaying of GnRH, LH, FSH and testosterone.
There were no significant differences in the levels of hormones between the groups of study.
Despite the central administration of camphor in hypothalamus - pituitary - gonad (HPG) axis, no significant differences were seen in sex hormone`s levels compared to the control. With this finding, it can be concluded that camphor may not effectively handle the axis via central pathway. These data recommend further studies of camphor on the HPG axis.
