Author/Authors :
Khodayari، Abbas نويسنده Karaj Branch, Islamic Azad University, Karaj, Iran , , Ghaderian، Seyyed Mohammad Hossein Seyyed Mohammad Hossein نويسنده Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran Ghaderian, Seyyed Mohammad Hossein Seyyed Mohammad Hossein , JAFARIAN، MOHAMMAD نويسنده , , Jahangirnia، Alireza Alireza نويسنده Department of Oral and Maxillofacial Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran Jahangirnia, Alireza Alireza , Mohajjel Nayebi، Alireza نويسنده Drug Applide Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Mohajjel Nayebi, Alireza , Akhlaghi، Fahimeh Fahimeh نويسنده Department of Oral and Maxillofacial Surgery, Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Akhlaghi, Fahimeh Fahimeh , Taghavi، Nasim نويسنده , , Akbarzadeh Najar، Reza Reza نويسنده Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran Akbarzadeh Najar, Reza Reza , Tabarestani، Sanaz Sanaz نويسنده Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran Tabarestani, Sanaz Sanaz , KHOJASTEH، ARASH نويسنده , , Aghabozorg Afjeh، Sarah Sarah نويسنده Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran Aghabozorg Afjeh, Sarah Sarah
Abstract :
Ameloblastic carcinoma (AC) is a rare malignant epithelial odontogenic tumor that histologically retains the features of ameloblastic differentiation and exhibits cytological features of malignancy in the primary or recurrent tumor. It may develop within a preexisting ameloblastoma or arise de novo or from an odontogenic cyst. Epidemiological evidence shows that human cancer is generally caused by genotoxic factors, genes involved in the susceptibility of cancer, including those involved in metabolism or detoxification of genotoxic environment and those controlling DNA replication. Nowadays, gene polymorphism has an important role in development of malignant tumor. We report a case series study of ameloblastic carcinoma and ameloblastoma to show the role of PKM2 and MAPK8IP2 polymorphisms in these tumors. The DNA was extracted separately from specimens in paraffin sections of the tumor. Polymorphism of these genes was determined by PCR-RFLP (Polymerase Chain Reaction-Restriction fragment length polymorphism) method. The allele distributions of all samples were in Hardy-Weinberg equilibrium. The genotype and allele distribution in these genes were not statistically different between patients and controls
