Author/Authors :
Kanliada، Deniz Deniz نويسنده Department of ORL and Head&Neck Surgery, Istanbul Faculty of Medicine, Istanbul, Turkey Kanliada, Deniz Deniz , Coskunpinar، Ender Ender نويسنده Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey Coskunpinar, Ender Ender , Serkan Orhan، Kadir Kadir نويسنده Department of ORL and Head&Neck Surgery, Istanbul Faculty of Medicine, Istanbul, Turkey Serkan Orhan, Kadir Kadir , Musteri Oltulu، Yasemin Yasemin نويسنده Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey Musteri Oltulu, Yasemin Yasemin , Celik، Mehmet Mehmet نويسنده Department of ORL and Head&Neck Surgery, Istanbul Faculty of Medicine, Istanbul, Turkey Celik, Mehmet Mehmet , Yaylim، Ilhan Ilhan نويسنده Department of Molecular Medicine, Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey Yaylim, Ilhan Ilhan , Deger، Kemal Kemal نويسنده Department of ORL and Head&Neck Surgery, Istanbul Faculty of Medicine, Istanbul, Turkey Deger, Kemal Kemal
Abstract :
The aim of this study is to determine whether there is a role of podoplanin and glutathione S-transferases T1 (GST-T1) expression in laryngeal squamous cell carcinoma.
The study was completed with 33 patients and gene expression analysis was performed by qRT–PCR. The podoplanin and GST-T1 expression patterns were analyzed to determine their correlation with clinicopathologic parameters of laryngeal cancer.
Of all patients, 20 had supraglottic, and the remaining 13 had glottic laryngeal cancer. Increased expression of podoplanin was found in 14 tumor tissues, but GST-T1 expression was not detected.
Podoplanin expression did not show any prediction for regional metastasis, thyroid cartilage invasion, lymphatic vessel invasion or tumor differentiation for laryngeal cancer, also there were no significant differences in podoplanin expression between glottic and supraglottic regions, but extracapsullar extension is almost statistically significant (p=0,05).
