Author/Authors :
Zarifian، Ahmadreza Ahmadreza نويسنده Student Research Assembly, Mashhad University of Medical Sciences, Iran Zarifian, Ahmadreza Ahmadreza , Farhoodi، Zeinab Zeinab نويسنده Student Research Assembly, Mashhad University of Medical Sciences, Iran Farhoodi, Zeinab Zeinab , Amel، Roya Roya نويسنده Student Research Assembly, Mashhad University of Medical Sciences, Iran Amel, Roya Roya , Mirzaee، Salmeh Salmeh نويسنده Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Iran Mirzaee, Salmeh Salmeh , Hassanzadeh-Nazarabadi، Mohammad نويسنده Medical Genetics Department, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Hassanzadeh-Nazarabadi, Mohammad
Abstract :
One of the major causes of spontaneous abortion before the fourth month of pregnancy is chromosomal abnormalities. We report an unusual case of a familial balanced chromosomal translocation in a consanguineous couple who experienced 4 spontaneous abortions. Chromosomal studies were performed on the basis of G-banding technique at high resolution and revealed 46, XX, t (16; 6) (p12; q26) and 46, XY, t (16; 6) (p12; q26) in both partners, which induced such pregnancy complications.
Chromosomal balanced translocation is one of the most common causes of recurrent spontaneous abortions (RSA). In such cases prenatal diagnosis (PND) during the 16th week of gestation is strongly recommended
