Effects of ivermectin on the activity of enzymes in mammalian cells in vitro Original Research Article

The effects of ivermectin on the activities of lactate dehydrogenase, glucose-6-phosphate dehydrogenase, and glucose-6-phosphatase have been estimated in IB-RS-2 cells in vitro. A 72-hr time course following ivermectin exposure indicated a decrease in the activity of lactate dehydrogenase. The activities of glucose-6-phosphate dehydrogenase and glucose-6-phosphatase remained essentially unchanged.