Acute toxicity of alkyl (1-phenylsulfonyl)cycloalsane-carboxylates to Daphnia magna and quantitative structure—Activity relationships

Acute toxicities of alkyl (1-phenylsulfonyl)cycloalkane-carboxylates to Daphnia magna are correlated by linear solvation energy relationships. The biological response, as a function of toxicant properties, is given by log1/LC50(mol/L) = 2.08(0.24) + 1.90(0.11)V1/100 − 1.20(0.24)β n=22 r=0.964 sd=0.085 log1/EC50(mol/L) = 2.45(0.27) + 1.91(0.13)V1/100 − 1.24(0.27)β n=22 r=0.955 sd=0.096> where V1 is the intrinsic solute molecular volume, β is the solvatochromic parameter that measures hydrogen bond basicity of the toxicant. The predicted values with above two equations are close to observed ones. The above equations also provide quantitative information on the factors affecting toxicity of alkyl (1-phenylsulfonyl) cycloalkane-carboxylates.